What are Concerns Regarding Endocrine Disruptors? In the last two decades there has been a growing awareness of the possible adverse effects in humans and wildlife from exposure to chemicals that can interfere with the endocrine system. These effects can include: developmental malformations, interference with reproduction, increased cancer risk; and disturbances in the immune and nervous system function. Clear evidence exists that some chemicals cause these effects in wildlife, but limited evidence exists for the potential of chemicals to cause these effects in humans at environmental exposure levels. Very few chemicals have been tested for their potential to interfere with the endocrine system. Current standard test methods do not provide adequate data to identify potential endocrine disruptors (EDs) or to assess their risks to humans and wildlife. In recent years, some scientists have proposed that chemicals might inadvertently be disrupting the endocrine system of humans and wildlife. A variety of chemicals have been found to disrupt the endocrine systems of animals in laboratory studies, and there is strong evidence that chemical exposure has been associated with adverse developmental and reproductive effects on fish and wildlife in particular locations. The relationship of human diseases of the endocrine system and exposure to environmental contaminants, however, is poorly understood and scientifically controversial (Kavlock et al., 1996, EPA, 1997).

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